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KMID : 0378019830260080084
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New Medical Journal
1983 Volume.26 No. 8 p.84 ~ p.90
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Effect of aspirin on diarrhea due to acute non-bacterial gastroenteritis in infants
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Abstract
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Clinical efficacy of aspirin on diarrhea due to non-bacterial gastroenteritis in 83 infants who were admitted to the department of pediatrics, Harping University Hospital from Sept. 1982 to Feb. 1983 was investigated. Diarrheal infants were divided into three groups. Group I consisted of 32 infants who were given aspirin 23-30mg/kg/day in divided doses, group II , 32 infants given kaopectin syrup 2cc/kg/day in divided doses and group 1, 21 infants given phenobarbital and pancre, atin. These three groups were statistically well matched.
Stool frequency and consistency were observed and compared between three groups during hospital admission. All diarrheal infants equally received intravenous fluid therapy in order to correct preexisting dehydration soon after admission and fluid balance was maintained throughout the hospital course.
Frequency of diarrhea and stool consistency were rapidly improved in group I as well as in group I. These successful effects in group I and group I were statistically significant when compared with those of group II. This result suggested that aspirin could be used for lowering the body temperature as well as for the management of infantile non-bacterial diarrhea.
Since successful effect was also noted in group I where supportive therapy was only given, the routine administration of aspirin for the purpose of only controlling diarrhea in infants was not recommended. Furthermore prior to administration of aspirin to the infnts suffering from diarrhea due to viral gastroenteritis, the possible mucosal damage and subsequent gastrointestinal bleeding by aspirin admistration should always be born in mind.
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